Yohimbine is a supplement that often shows up in conversations about fat loss and sexual performance. Some see it as a fat burner, others as a possible support for erectile issues. But the reality is more complex than marketing claims. Here’s what the science says — in plain terms.
What Is Yohimbine
Yohimbine is a compound found in the bark of the yohimbe tree. It works as a stimulant and blocks alpha-2 adrenergic receptors. That may help the body mobilize fat and improve blood flow — including to the pelvic area. That’s why it was once sold as a prescription treatment for erectile dysfunction.
Does It Help with Erectile Dysfunction
Yes, there’s some evidence. Yohimbine was used as a drug for erectile dysfunction in the past. Studies found it worked better than placebo in men with mild to moderate symptoms. One clinical trial showed improvements in 71% of men taking yohimbine, compared to 45% on placebo (Vogt et al., 1997).
Other research confirmed this trend (Rowland et al., 1997, Ernst & Pittler, 1998). But the results aren’t consistent in every case. In more severe forms of ED, yohimbine may be less effective.
Can It Help with Fat Loss
Yohimbine may support fat loss — especially in those hard-to-burn areas like the lower back and belly in men. It works by targeting fat receptors that slow down fat breakdown.
In one study, soccer players who took 20 mg of yohimbine daily for 21 days lost more body fat than those on placebo, with no drop in performance or side effects (Ostojic, 2006).
But there’s a catch: it only works when fasting. If you take it with food or right after a meal, insulin blocks its effect. That’s why it’s usually taken first thing in the morning or at least 2.5 hours after eating.
What About Focus and Mood
Some use yohimbine as a light nootropic. It can give a temporary boost in energy, mood, and social confidence — especially when paired with caffeine and L-tyrosine. But for others, it causes tension or restlessness. The effect varies. For some, it’s motivation. For others — anxiety.
Side Effects and Risks
Yohimbine can increase anxiety, heart rate, and blood pressure. That’s especially risky for people with panic tendencies or heart issues.
Another big concern is product quality. A study tested 49 supplements and found that the actual amount of yohimbine ranged from 23% to 147% of what was listed on the label (Cohen et al., 2015). That makes dosing unpredictable.
Yohimbine can also interact with medications, especially psychiatric or blood pressure drugs. Combining it with strong stimulants like ephedrine can be dangerous.
How to Use It Safely
The common dosage is 0.2 mg per kg of body weight. For an 80 kg man, that’s about 16 mg. It’s best to start with less and see how your body responds.
Most people use it during the final stages of cutting, when regular diet and training stop giving results. A typical protocol might include caffeine, yohimbine, and L-tyrosine taken on an empty stomach before light cardio (like jogging or jump rope). Some follow it with a protein shake, others continue fasting.
What to Keep in Mind
Yohimbine isn’t a magic fix. It might help in specific cases — especially for stubborn fat or mild erectile issues — but it has limits. If your diet, training, and sleep aren’t in check, no supplement will replace that.
And if you decide to try it, be cautious. Look for reputable brands. Start small. If you’re on medication, talk to your doctor first.