Muira puama, often called “potency wood” or “Amazonian Viagra,” is a plant native to the Amazon rainforest. Traditionally used to fight fatigue and sexual dysfunction, it has gained popularity as a supplement targeting male performance and vitality. But what does the research actually show?
Libido and Erectile Function
Muira puama’s reputation is largely built on its historical use as an aphrodisiac. In Brazil, it’s still listed in the national pharmacopoeia for this purpose. Some clinical studies provide early support for its effect on male sexual function.
One open-label trial in men with low libido found that 60–70% reported increased sexual desire and improved erectile function after two weeks of taking muira puama extract (Drugs.com).
Another study tested a supplement called Revactin®, which includes muira puama among other ingredients. Researchers observed activation of the nitric oxide pathway in smooth muscle cells — a key mechanism behind improved blood flow during erections, similar to how PDE5 inhibitors like sildenafil work (PMID: 33425731).
Effects have also been studied in women. A small trial involving 202 women with low sex drive found that 65% experienced improved sexual desire and satisfaction after one month of supplementation (Drugs.com).
Possible Mechanisms
Muira puama contains plant sterols, which serve as building blocks for sex hormones like testosterone. Lab studies suggest that its extracts help relax the corpus cavernosum — the erectile tissue in the penis — improving blood flow during arousal (PMID: 33425731).
Energy, Focus, and Memory
Beyond its effects on libido, muira puama is also used as a tonic for fatigue and low stamina. It has long been applied in traditional medicine as a general nerve stimulant. Some modern studies are starting to explore its influence on brain function.
Animal studies have shown memory-enhancing effects, possibly due to its ability to inhibit acetylcholinesterase — the enzyme that breaks down acetylcholine, a key neurotransmitter for learning and memory (Phytomedicine, 2010).
In one study, older mice treated with muira puama extract performed better in memory tasks compared to untreated animals. These findings suggest a possible role in cognitive support, although human trials are still lacking (Global Healing).
Safety and Side Effects
Muira puama is generally considered safe when used appropriately. Reported side effects include insomnia, headaches, nausea, and digestive discomfort. There are also some concerns about potential interactions with medications for blood pressure and blood thinning. If you’re on any regular medication, it’s worth speaking with your doctor first.
How to Take It
Muira puama supplements are available in tincture, capsule, and powdered forms. Typical dosing for tinctures is 2–4 ml twice per day, but this can vary depending on concentration. It’s best to start with a low dose and monitor how your body responds.
Final Thoughts
Muira puama is a plant with a long history and a growing interest in modern health contexts. While early research is promising — particularly for libido and erectile support — the scientific evidence is still developing. Most studies are small and short-term, and more rigorous clinical trials are needed.
If you’re thinking about trying muira puama, approach it like any supplement: with curiosity and caution. It may be a useful addition to a broader strategy for men’s health, but it’s not a substitute for good sleep, physical activity, balanced nutrition, and stress management.